NN&I - August 2010

" " " This therapy and system have changed my life.* David RUSH, Hip-hop artist What does freedom mean to a NxStage® patient? What should the NxStage FREEDOM study mean to you?* Home daily therapies are not for everyone. They require a patient and partner who are committed to being trained on and following the guidelines for proper system operation, as well as their dialysis prescription, which may require treatments up to six days per week. The NxStage System One is a prescription device and, like all medical devices, involves some risks. Patients should consult with their doctor to understand the risks and responsibilities of home and/or daily hemodialysis using the NxStage System One. The experiences reported here may not necessarily be experienced by another patient. All patients differ, and their experiences will vary. ** FREEDOM study references, primary publication data, and interim updates are available by request or on www.nxstage.com. \206 Data on sleep quality, Restless Legs Syndrome, and health-related QOL measures are from 4 month interim analysis. All other data is from 12 month interim analysis.© 2010 NxStage Medical, Inc. NxStage® is a registered trademark of NxStage Medical, Inc. System One™ is a trademark of NxStage Medical, Inc. CAUTION: Federal law restricts these devices to sale by or on the order of a physician. APM473 Rev. A The largest of its kind, the NxStage FREEDOM study (Following Rehabilitation Economics and Everyday-Dialysis Outcome Measurements)** is designed to compare the clinical and economic bene\037ts of more frequent home hemodialysis with traditional, thrice-weekly in-center hemodialysis. The study's interim \037ndings include:\206 Signi\037cant improvement in post-treatment recovery time Signi\037cant improvement in depressive symptoms Signi\037cant improvement in sleep quality Signi\037cant reduction in expected mortality rate Signi\037cant reduction in anti-hypertensive medication use Signi\037cant improvement in health-related QOL measures Signi\037cant reduction in symptoms of Restless Legs Syndrome Learn more about the NxStage FREEDOM study and request additional information at nxstage.com/freedomstudy Ads_NNI0810.indd 39 7/12/10 2:54:16 PM